Diagnosis, Prognosis, and Treatment of Impaired Glucose Tolerance and Impaired Fasting Glucose
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چکیده
Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are the intermediate metabolic states between normal and diabetic glucose homeostasis. These conditions are thought to be the precursors of DM, but the progression to overt disease is not straightforward. The risk for both macrovascular and microvascular complications increases across the distribution of blood glucose concentrations well below the overt DM, and the risk is more strongly associated with post-challenge hyperglycemia than fasting glucose levels. However, it is unclear whether this “glucose effect” is independent of classical risk factors, such as blood pressure and lipids, or occurs due to abnormalities of other metabolites, such as free fatty acids.
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